RNA Details
Disease Name
idiopathic pulmonary fibrosis
Tissue
lung
RNA Symbol
Sirt1
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
Immunohistochemistry; H&E etc.
Target
Sirt1
Pathway
NA
PubMed ID
Title
P53 and miR-34a Feedback Promotes Lung Epithelial Injury and Pulmonary Fibrosis
Year
2017
Function
"P53 and apoptosis is induced with suppression of urokinase-type plasminogen activator (uPA) and the uPA receptor in AECs from the lungs of IPF patients and in mice with lung injury. Treatment with the caveolin-1 scaffolding domain peptide (CSP) reversed these effects. AECs from IPF lungs or mice with diverse types of lung injuries showed increased p53 acetylation and miR-34a expression with reduction in Sirt1. Bleomycin failed to induce miR-34a in p53- or plasminogen activator inhibitor-1 (PAI-1)-deficient mice. CSP-mediated inhibition of miR-34a restored Sirt1, suppressed p53 acetylation and apoptosis in injured AECs, and prevented pulmonary fibrosis (PF). AEC-specific suppression of miR-34a inhibited bleomycin-induced p53, PAI-1, and apoptosis and prevented PF, whereas overexpression of precursor-miR-34a increased p53, PAI-1, and apoptosis in AECs of mice unexposed to bleomycin. P53 and miR-34a Feedback Promotes Lung Epithelial Injury and Pulmonary Fibrosis."